Studies on Tumor Immunity

Studies on Pneumococcus Immunity

1. Active immunity against many lethal doses of Pneumococcus Types I, II, and III may be produced in mice by two or three subcutaneous injections of the homologous type of pneumococcus saline vaccine. 2. Mice may be actively immunized with the protein fraction obtained by treating pneumococci with anhydrous sodium sulfate or by solution of pneumococci in bile salts and precipitation with alcoho...

Studies on Antiblastic Immunity

Antipneumococcus serum under certain conditions apparently inhibits or retards the metabolic activities of the homologous pneumococcus. Antipneumococcus serum exhausted of its agglutinin content possesses no inhibitory properties. The degree of inhibitory action of antipneumococcus serum parallels its agglutinating power. No evidence has been found to indicate that the inhibition of the metabol...

Studies on Immunity in Cancers

Studies on Immunity in Anthrax

Non-proteolytic mutants were isolated from the Vollum strain of B. anthracis following ultraviolet treatment. The mutants were virulent for rabbits and mice and their non-proteolytic character was stable in culture and on serial passage in rabbits. The mutants produced protective antigen under suitable conditions of cultivation in vitro, and allowed longer incubation of the cultures without des...

Diffusion Chamber Studies of Allogenic Tumor Immunity in Mice '

allow the passage of essential metabolites but prevent the passage of intact cells, have been used to study in vivo immunologic mechanisms for some years. Various workers have concluded from their studies that viable allogenic tissue, including tumor tissue, implanted within such chambers does not induce host immunity. The basic support for this conclusion is the excellent work of Algire (1, 2)...